Document Details

Document Type : Article In Journal 
Document Title :
Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer
Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer
 
Document Language : English 
Abstract : Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and early event almost uniquely observed in colorectal tumorigenesis. Alterations in the APC gene generate truncated gene products, leading to activation of the Wnt signaling pathway and deregulation of multiple other cellular processes. It has been a mystery why most patients with CRC retain a truncated APC protein, but accumulating evidence suggest that these C terminally truncated APC proteins may have gain of function properties beyond the well-established loss of tumor suppressive function. Here, we will review the evidence for both the loss of function and the gain of function of APC truncations and how together they contribute to CRC initiation and progression. 
ISSN : 0027-8874 
Journal Name : JNCI: Journal of the National Cancer Institute 
Volume : 109 
Issue Number : 8 
Publishing Year : 1438 AH
2017 AD 
Article Type : Article 
Added Date : Tuesday, June 25, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Lu ZhangZhang, Lu ResearcherDoctorate 
Jerry W. ShayShay, Jerry W.InvestigatorDoctoratejerry.shay@utsouthwestern.edu

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