Document Details
|
Document Type |
: |
Article In Journal |
|
Document Title |
: |
Evaluation of InnoTyper® 21 in a sample of Rio de Janeiro population as an alternative forensic panel Evaluation of InnoTyper® 21 in a sample of Rio de Janeiro population as an alternative forensic panel |
|
Document Language |
: |
English |
|
Abstract |
: |
The use of bi-allelic markers such as retrotransposable element insertion polymorphisms or Innuls (for insertion/null) can overcome some limitations of short tandem repeat (STR) loci in typing forensic biological evidence. This study investigated the efficiency of the InnoTyper® 21 Innul markers in an urban admixed population sample in Rio de Janeiro (n = 40) and one highly compromised sample collected as evidence by the Rio de Janeiro police. No significant departures from Hardy-Weinberg equilibrium were detected after the Bonferroni correction (α′ ≈ 0.05/20, p < 0.0025), and no significant linkage disequilibrium was observed between markers. Assuming loci independence, the cumulative random match probability (RMP) was 2.3 × 10−8. A lower mean Fis value was obtained for this sample population compared with those of three North American populations (African-American, Southwest Hispanic, US Caucasian). Principal component analysis with the three North American populations and one from 21 East Asian population showed that African Americans segregated as an independent group while US Caucasian, Southwest Hispanic, East Asian, and Rio de Janeiro populations are in a single large heterogeneous group. Also, a full Innuls profile was produced from an evidence sample, despite the DNA being highly degraded. In conclusion, this system is a useful complement to standard STR kits. |
|
ISSN |
: |
1437-1596 |
|
Journal Name |
: |
International Journal of Legal Medicine |
|
Volume |
: |
132 |
|
Issue Number |
: |
1 |
|
Publishing Year |
: |
1439 AH
2018 AD |
|
Article Type |
: |
Article |
|
Added Date |
: |
Thursday, June 20, 2019 |
|
Researchers
| Rodrigo S. Moura-Neto | Moura-Neto, Rodrigo S. | Investigator | Doctorate | rodrigomouraneto@ufrj.br |
| I. C. T. Mello | T. Mello, I. C. | Researcher | Doctorate | |
| Rosane Silva | Silva, Rosane | Researcher | Doctorate | |
| Carolina G. Bottino | Bottino, Carolina G. | Researcher | Doctorate | |
| A. Woerner | Woerner, A. | Researcher | Doctorate | |
| Jonathan L King | King, Jonathan L | Researcher | Doctorate | |
| Frank Wendt | Wendt, Frank | Researcher | Doctorate | |
| Bruce Budowle | Budowle, Bruce | Researcher | Doctorate | |
|
Back To Researches Page
|