Document Details
|
Document Type |
: |
Article In Journal |
|
Document Title |
: |
A lipidomic and metabolomic serum signature from nonhuman primates exposed to ionizing radiation A lipidomic and metabolomic serum signature from nonhuman primates exposed to ionizing radiation |
|
Document Language |
: |
English |
|
Abstract |
: |
Introduction Due to dangers associated with potential
accidents from nuclear energy and terrorist threats, there is
a need for high-throughput biodosimetry to rapidly assess
individual doses of radiation exposure. Lipidomics and
metabolomics are becoming common tools for determining
global signatures after disease or other physical insult and
provide a ‘‘snapshot’’ of potential cellular damage.
Objectives The current study assesses changes in the
nonhuman primate (NHP) serum lipidome and metabolome
7 days following exposure to ionizing radiation (IR).
Methods Serum sample lipids and metabolites were
extracted using a biphasic liquid–liquid extraction and
analyzed by ultra performance liquid chromatography
quadrupole time-of-flight mass spectrometry. Global radiation
signatures were acquired in data-independent mode. |
|
ISSN |
: |
1573-3882 |
|
Journal Name |
: |
Metabolomics |
|
Volume |
: |
12 |
|
Issue Number |
: |
5 |
|
Publishing Year |
: |
1437 AH
2016 AD |
|
Article Type |
: |
Article |
|
Added Date |
: |
Thursday, July 20, 2017 |
|
Researchers
| Evan L. Pannkuk | Pannkuk, Evan L. | Researcher | Doctorate | |
| Evagelia C. Laiakis | Laiakis, Evagelia C. | Researcher | Doctorate | |
| Tytus D. Mak | Mak, Tytus D. | Researcher | Doctorate | |
| Giuseppe Astarita | Astarita, Giuseppe | Researcher | Doctorate | |
| Simon Authier | Authier, Simon | Researcher | Doctorate | |
| Karen Wong | Wong, Karen | Researcher | Doctorate | |
| Albert J. Fornace Jr | Fornace Jr, Albert J. | Researcher | Doctorate | |
|
Back To Researches Page
|